Azithromycin for Sinusitis, Bronchitis
Azithromycin (Z-pack, Zithromax) is currently recommended by several medical societies for the treatment of community-acquired pneumonia, acute exacerbations of chronic bronchitis, and acute bacterial sinusitis.
Azithromycin for Sinus infection
Azithromycin is used to treat acute sinus infections. It achieves excellent mucosal levels but is considered a second-line choice. Also, azithromycin is not recommended for chronic sinusitis (which lasts more than 3 months).
Azithromycin (Z-Pack) dosage for sinusitis:
How long does it take for azithromycin to work? It takes until day 3 before your really start feeling better. Azithromycin concentrations in sinus fluids are maintained up to 120 h, so continues to work 5-6 days after you finish it 2.
How effective is azithromycin? One study found that a 3-day course of azithromycin was as effective as a 10-day course of amoxicillin/clavulanate in treating acute sinusitis 1. However, azithromycin is not likely an optimal choice in sinusitis because of increased Pneumococcal resistance to macrolides.
Azithromycin for Bronchitis
Azithromycin is commonly used in the treatment of acute exacerbations of chronic bronchitis and acute bronchitis4 (a transient inflammation of the trachea and bronchi).
Independent of its potent antimicrobial activity, azithromycin possesses anti-inflammatory properties that contributes to benefits in patients with airway inflammation. Azithromycin can normalize bronchial and nasal mucus secretion, and may reduce bronchial hyperresponsiveness and sputum purulence.
Azithromycin (Z-Pack) dosage for acute bronchitis: 500 mg initially, then 250 mg daily for 4 days.
How quickly does azithromycin begin working? Azithromycin is bacteriostatic. Bacteriostatic antibiotic stops the growth of bacteria and works slower than bactericidal, which kills bacteria. So it takes time to notice the improvement with azithromycin.
Note: Antibiotics are generally not indicated for bronchitis, and should be used only if pertussis is suspected or if the patient is at increased risk of developing pneumonia5.
Author: OriginalDrugs Team