Metronidazole vs Tinidazole

Tinidazole, a newer nitroimidazole, is very similar to metronidazole.

Both tinidazole and metronidazole are equally effective for bacterial vaginosis (BV) 1.

Tinidazole appears to have small advantage over metronidazole in the treatment of trichomoniasis, and may work against metronidazole-resistant Trichomonas vaginalis.

Tinidazole is superior to metronidazole in the treatment of amebiasis and amebic liver abscess 3.

Tinidazole is better tolerated and has lower incidence of gastrointestinal side effects and metallic taste in comparison to metronidazole 2.

Tinidazole has a longer half-life than metronidazole (12-14 hours versus 8 hours), allowing for a less frequent and shorter regimen.

Metronidazole is considerably cheaper and available in generic form. It is also available in an intravenous and topical formulations.

See also


  • 1. Schwebke JR, Desmond RA. Tinidazole vs metronidazole for the treatment of bacterial vaginosis. Am J Obstet Gynecol. 2011 Mar;204(3):211.e1-6. PubMed
  • 2. Armstrong NR, Wilson JD. Int J Womens Health. 2010 Aug 9;1:59-65.
  • 3. Swami B, Lavakusulu D, Devi CS. Tinidazole and metronidazole in the treatment of intestinal amoebiasis. Curr Med Res Opin. 1977;5(2):152-6.

Author: OriginalDrugs Team
Last reviewed: February 14, 2015