Paroxetine (Paxil)

Paxil and Premature Ejaculation

Delayed ejaculation is a well known side effect of paroxetine. However this trait can be useful for men with premature ejaculation. Paroxetine increases the latent period of intravaginal ejaculation (time between the start of penetrative intercourse and ejaculation).

Paroxetine with sildenafil (Viagra) helps premature ejaculation better than paroxetine alone1.

Dose for premature ejaculation: 10–40 mg once daily; or 20 mg taken 3–4 hours before planned intercourse.

Paxil and Anxiety

Paroxetine was the first antidepressant formally approved in the United States for the treatment of social anxiety disorder, causing it to be sometimes referred to (although inaccurately) as an anti-shyness drug.

Paroxetine reduces anxiety, feelings of anger, paranoid thoughts, and pressure in social situations. The general mood is positively improved; the abilities to focus on tasks, cope with stressors, and move forward in your life are increased. A more positive outlook and social interaction are much easier to achieve.

Paroxetine significantly reduces and even eliminates the panic attacks.

Dose for Panic disorder: Initially, 10 mg a day. Increase if needed by 10 mg/day increments at intervals of at least 1 week. The target dose is 40 mg daily.

Dose for GAD, Social anxiety, Post-traumatic stress disorder: 20 mg once daily; range 20-60 mg/day.

Paxil and OCD

Paroxetine reduces frequency of obsessive thoughts, time spent performing compulsive acts, and degree of anxiety.

Dose for obsessive-compulsive disorder: Initially, 20 mg once daily. Increase if needed by 10 mg/day increments at intervals of at least 1 week. The recommended long-term dose is 40 mg daily. The maximum is 60 mg a day.

Paxil and Depression

Paroxetine is "broad-spectrum" antidepressant effective for depression of all types including mild, moderate and severe depression. Paroxetine is a good choice in anxious depression, when it is accompanied by high levels of anxiety. It is also helpful in the prevention of depressive relapse.

Geriatric depression
Paroxetine is used to treat depression in elderly persons. However, paroxetine is not a favored treatment due to its anticholinergic properties. This SSRI is very sedating and may cause drowsiness, cognitive flattening, apathy, and delirium. Generally, it is recommended to avoid paroxetine in elderly people.

Dose for depression: Initially, 20 mg once daily. Increase if needed by 10 mg/day increments at intervals of at least 1 week, up to a maximum of 50 mg a day.

Acute episodes of depression require several months or longer of antidepressant therapy. Paroxetine efficacy is maintained for periods of up to 1 year.

It takes about 4-6 week for paroxetine to start working.


See also


  • 1. Salonia A, Maga T, Colombo R, Scattoni V, Briganti A, Cestari A, Guazzoni G, Rigatti P, Montorsi F. A prospective study comparing paroxetine alone versus paroxetine plus sildenafil in patients with premature ejaculation. J Urol. 2002 Dec;168(6):2486-9.

Author: OriginalDrugs Team
Last reviewed: February, 2015

Quick facts

  • Premature ejaculation (also known as rapid ejaculation) is a lack of control over ejaculation so that it often happens sooner than desired.