Sertraline (Zoloft) for Depression
Sertraline is one of the best antidepressants for depression. There is evidence-based, unbiased proof that it is a worthy antidepressant choice.
Recently researchers analyzed and compared 12 new-generation antidepressants1. They found out that the most effective and best tolerated as first-line treatments are sertraline (Zoloft) and escitalopram (Lexapro).
Sertraline success rate
More than 70% depressed patients benefit from treatment with sertraline 6, 7.
Sertraline was found to be more effective than duloxetine by 30%, fluoxetine by 25%, and paroxetine by 25%1. However, the findings don't mean that everyone should start from Zoloft.
Sertraline and postpartum depression
Depression after pregnancy is called postpartum depression. This type of depression occurs in 10 to 15% of women within the first 3 months after giving birth.
Sertraline is often used to treat postpartum depression because it appears in breast milk in small amounts and is usually not detected in infants5. In fact, it is the most widely studied and safest antidepressant in breast-feeding women.
Immediate postpartum period is a high-risk time for depression, especially in women who have had previous depressive episodes. One study found that sertraline is effective in preventing postpartum depression4.
How long does it take for Sertraline to work?
The time it takes for sertraline to start working varies from person to person. Improvement may not be seen for several days to a few weeks.
With the dose 50 mg/day improvement in symptoms is noted after 6 weeks in about 20% of patients and with the dose 100 mg/day improvement is noted after 4 weeks in about 40% of patients2.
Author: OriginalDrugs Team