Spironolactone (Aldactone) for PCOS

Spironolactone is often used in women with PCOS and who are "hirsute" (have extra hair in unwanted places)1.

Spironolactone is superior to metformin for the treatment of polycystic ovary syndrome (PCOS) 2. It reduces androgen levels and excess facial hair (hirsutism), and improves menstrual cycle frequency. However, if insulin resistance is the basic pathogenic factor, then metformin privides superior effects on glucose tolerance.

Recent research indicates that spironolactone may be used in combination with licorice to reduce undesirable diuretic effects 3.

Spironolactone dose range for PCOS is 50 to 200 mg daily. It can take up to 6 months to see an improvement in hirsutism and other PCOS symptoms.

See also


  • 1. Zulian E, Sartorato P, Benedini S, Baro G, Armanini D, Mantero F, Scaroni C. Spironolactone in the treatment of polycystic ovary syndrome. J Endocrinol Invest. 2005 Jan;28(1):49-53. PubMed
  • 2. Ganie MA, Khurana ML, Eunice M, Gupta N, Gulati M, Dwivedi SN, Ammini AC. Comparison of efficacy of spironolactone with metformin in the management of polycystic ovary syndrome. J Clin Endocrinol Metab. 2004 Jun;89(6):2756-62.
  • 3. Armanini D, Castello R, Scaroni C, et al. Eur J Obstet Gynecol Reprod Biol. 2007 Mar;131(1):61-7.

Author: OriginalDrugs Team
Last reviewed: February, 2015

  • Spironolactone seem to be similarly effective for reducing hirsutism as flutamide and finasteride.