Cyclobenzaprine (Flexeril) vs Tizanidine (Zanaflex)

Tizanidine (Zanaflex) is an antispastic muscle relaxant indicated to manage spasticity, but practically is often used to treat muscle spasms. It has a very short half-life of 2.5 hours.

Cyclobenzaprine (Flexeril) is an antispasmodic muscle relaxant and is mainly used in musculoskeletal conditions such as neck or back pain and muscle injuries. The half-life of cyclobenzaprine is much longer - 18 hours.

Both have proven benefits in back pain and fibromyalgia. Both are sedatives and are very helpful for sleep disturbances.

Some people report tizanidine is stronger and works better than cyclobenzaprine.
Read more about which is stronger Cyclobenzaprine or Tizanidine? on Drugs.com.

See also

Author: OriginalDrugs Team
Last reviewed: February, 2015

Quick facts


  • Cyclobenzaprine is roughly equivalent to diazepam in the treatment of musculoskeletal conditions.