Ultracet vs Other Pain Relievers

Ultracet is a combination of opioid analgesic tramadol (37.5 mg) and non-opioid, non-salicylate analgesic acetaminophen (325 mg). It is approved for short term management of acute pain. Ultracet provides rapid and long-lasting pain relief.

The following information would be helpful for our visitors in choosing the right medication.

Ultram vs Ultracet

Ultram contains 50 mg tramadol only, no any other active ingredients.
Ultracet contains 37.5 mg tramadol plus 325 mg acetaminophen.

Clinical trials have shown that Ultracet is more effective and provides a faster onset of analgesia than tramadol alone. Also, lower amount of tramadol results in improved tolerability.

Ultracet vs Hydrocodone/Acetaminophen (Lorcet, Lortab, Norco, Vicodin)

According to the clinical study, Ultracet provides effective rapid analgesia comparable to that of Hydrocodone/Acetaminophen (Lorcet) with lower rate of side effects1. In the study the onset of pain relief was about 34 minutes with Ultracet and 25.4 minutes with Hydrocodone/Acetaminophen. The incidence of nausea and vomiting was about 50% lower with Tramadol/Acetaminophen combination.

Results of the ankle sprain study showed that Ultracet and Hydrocodone/Acetaminophen had comparable utility in relieving pain caused by ankle sprain4.

Ultracet vs Codeine/APAP

The results of another study suggest that Ultracet (37.5 mg/325 mg) is as effective as Codeine/APAP (30 mg/300 mg) in the treatment of chronic low back pain and osteoarthritis pain. Codeine/APAP causes higher rate of sleepiness and constipation whereas Ultracet causes more headaches2.

Ultracet vs Gabapentin

Ultracet is as effective in relieving painful diabetic neuropathy as gabapentin, according to the Korean study. The overall improvements in pain intensity were –3.11 and –2.70 for the tramadol/acetaminophen and gabapentin groups respectively5.

See also


  • 1. Fricke JR, Karim R, Jordan D, Rosenthal N. Comparison of the analgesic efficacy of tramadol/acetaminophen, hydrocodone/acetaminophen, and placebo after oral surgery. Clin Ther. 2002 Jun;24(6):953-68.
  • 2. Mullican WS, Lacy JR; TRAMAP-ANAG-006 Study Group. Tramadol/acetaminophen combination and codeine/acetaminophen combination for the management of chronic pain: a comparative trial. Clin Ther. 2001 Sep;23(9):1429-45. PubMed
  • 4. Hewitt DJ, Todd KH, Xiang J, et al. Tramadol/acetaminophen or hydrocodone/acetaminophen for ankle sprain: a randomized, placebo-controlled trial. Ann Emerg Med. 2007 Apr;49(4):468-80, 480.e1-2.
  • 5. Ko SH, Kwon HS, Yu JM, et al. Comparison of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy. Diabet Med. 2010 Sep;27(9):1033-40. PubMed

Author: OriginalDrugs Team
Last reviewed: February, 2016

Quick facts

  • According to the research, it is an effective analgesic in chronic low back pain and fibromyalgia without any serious side effects.