Budeprion XL

  • Generic name: Bupropion hcl
  • Brand names: Budeprion; Budeprion XL
  • Therapeutic class: Antidepressant, Norepinephrine and Dopamine Reuptake Inhibitor

What is Budeprion XL used for?

  • Depression
  • Seasonal affective disorder
  • Smoking cessation

Budeprion XL (manufactured by Teva) is the FDA approved generic version of Wellbutrin XL®.

Difference between Budeprion and Bupropion

Budeprion XL® is the bupropion hcl extended-release manufactured by Teva Pharmaceuticals.

Bupropion XL is the bupropion hcl extended-release manufactured by Watson Laboratories.

So Budeprion and Bupropion contain the same active drug. However, there is a real difference between the two generics. Compared to original Wellbutrin XL® and other generics, the Teva product contains an inferior delivery mechanism for the active drug. This explains why many people who have used both medications claim that they have reacted very differently to them.

Watson Pharmaceuticals and Anchen Pharmaceuticals developed a generic Bupropion XL product with a membrane release technology, which more or less resembles sophisticated membrane-release technology developed by GSK for original Wellbutrin XL®.

Teva's Budeprion XL®, unlike other generics, relies on inferior and older matrix technology. As a result, Budeprion XL®, releases its active ingredient 4 times faster during the first 2 hours than does original Wellbutrin XL® or other generics (such as Watson).

Important note: Matrix release mechanism is utilized in immediate-release (IR) and sustained-release (SR) formulations of bupropion.

Further reading


  • 1. Kathrynne Holden "Wellbutrin: Generic Drug May Not Equal Original".
  • 2. Notice of Class Action Settlement - Budeprion XL Settlement PDF

Last updated: February, 2015

Good to know

Budeprion XL 300mg

  • Budeprion uses a matrix of materials that expands when wet and then breaks apart to release the ingredient.