Doxycycline Hyclate (Vibramycin)
What is Doxycycline used for?
Doxycycline is available in several different salts: monohydrate, hyclate (hydrochloride anhydrous), carrageenate, calcium, and phosphate (fosfatex). The therapeutic properties of the different salts do not significantly differ.
Difference between Doxycycline Hyclate vs Monohydrate
Doctors often write prescriptions for doxycycline without specification of which formulation to dispense. Both doxycyclines are equally effective. But sometimes medical practitioners prefer the monohydrate salt because it dissolves slower in the stomach and potentially has less gastrointestinal side effects than standard doxycycline hyclate capsules or tablets 1.
However, an increased stomach pH decreases the bioavailability of doxycycline monohydrate whereas the absorption of hyclate is independent of pH. Plus monohydrate version is more expensive.
Difference between Doryx and Doxycycline
Doryx is a delayed-release formulation of doxycycline hyclate marketed by Warner Chilcott. The essential difference is Doryx contains specially enteric-coated pellets of doxycycline that pass through the stomach and dissolve only after reaching the small intestine. This helps to reduce gastrointestinal irritation. Doryx can be taken once a day anytime, with or without food or milk.
And, of course, the cost of doxycycline is significantly lower in comparison with Doryx.
Is Oracea different from Doxycycline?
Oracea is a 40 mg capsule of doxycycline monohydrate, containing 30 mg immediate-release and 10 mg delayed-release doxycycline beads. It is licenced for the treatment of rosacea only. The dosage of Oracea differs from that of doxycycline used to treat infections.
Long-term risks of Doxycycline
Prolonged use of doxycycline is usually safe 2. According to the UK Advisory Committee for Malaria Prevention (ACMP), there is no evidence of harm in long-term use of doxycycline and it may be taken safely for periods of at least up to two years3.
Last updated: February, 2015
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