Fluconazole (Diflucan)

  • Generic name: Fluconazole
  • Brand name: Diflucan, CanesOral (Canada)
  • Class: Antifungal agent, Triazoles

What is Fluconazole used for?

  • Fungal and yeast infections, particularly those caused by Candida or Cryptococcus species of fungi: vaginal thrush, systemic candidiasis, cryptococcal meningitis.
  • Dermatophyte infections: ringworm, jock itch, Athlete's foot, and onychomycosis (nail fungus).

Notice: Fluconazole does NOT treat trichomoniasis 1.


  • Hypersensitivity to fluconazole.
  • Concomitant use with terfenadine, astemizole, cisapride, pimozide, or quinidine.

Fluconazole has been linked to rare cases of serious liver damage, including deaths, mostly in persons with serious health problems.

Serious drug interactions

Generally, fluconazole has a lower potential for drug interactions than other azole antifungals.

  • Amphotericin B: possible antagonistic interaction; reduced therapeutic effect of amphotericin B.
  • Benzodiazepines (alprazolam, midazolam, triazolam): increased peak plasma concentrations of benzodiazepines
  • Carbamazepine: increased carbamazepine concentrations and risk of intoxication.
  • Phenytoin, fosphenytoin: increased phenytoin concentrations and AUC and risk of intoxication; use concomitantly with great caution
  • Antidiabetic agents, sulfonylureas (glipizide, glyburide, tolbutamide): increased plasma concentrations of the antidiabetic agent and risk of hypoglycemia; monitor blood glucose.
  • Corticosteroids (e.g, prednisone): decreased metabolism of corticosteroids; if used concomitantly for prolonged periods, carefully monitor for adrenal cortex insufficiency when fluconazole is discontinued.
  • Losartan: possibility of decreased losartan therapeutic effect.
  • Lurasidone: increase lurasidone concentration.
  • Opiate agonists (alfentanil, fentanyl, methadone): elevated opioid concentration, which may lead to QT-prolongation and respiratory depression.
  • Statins (e.g., fluvastatin, lovastatin, simvastatin): increased risk of myopathy and rhabdomyolysis.
  • Theophylline: increased theophylline concentrations.
  • Rifampin, rifabutin: decreases level of fluconazole and possible decreased efficacy.
  • Warfarin: increased prothrombin time and risk of bleeding events.


LLast updated: February, 2015

Good to know

  • Fluconazole is the first member of a new subclass of synthetic triazole antifungal agents.
  • With Fluconazole you may notice an improvement in your symptoms in one day.
  • It is distinguished from the other azole antifungal because of its water solubility, CNS penetration, excellent oral bioavailability, and least effect on hepatic enzymes.