Minocycline (Minocin)

  • Generic name: Minocycline
  • Brand names: Dynacin, Minocin
  • Drug class: Tetracycline antibiotic

What is Minocycline used for?

  • Acne
  • Respiratory tract infections
  • Urinary tract infections
  • Skin infections, periodontitis
  • Sexually transmitted diseases
  • Rheumatoid arthritis

Warnings & Precautions

  • Do not take minocycline if you have history of allergic reaction to any tetracycline antibiotic.
  • Not recommended in children <8 years, pregnant women, and breast-feeding mothers. May cause discoloration of teeth and problems with bone growth in young children and infants.
  • Minocycline has been reported to cause rare life-threatening events, such as hypersensitivity syndrome reaction, serum sicknesslike reaction, and lupus-like syndrome.
  • -May cause blue-black pigmentation of gums, skin, and nails.
  • May cause CNS symptoms such as light-headedness, dizziness, and vertigo.

Can you take Minocycline with milk?

Minocycline absorption is not affected by dairy products or other food. It may be taken without dietary restrictions.

Alternatives to Minocycline

Doxycycline hyclate is a cheaper and safer alternative to minocycline. Both antibiotics are equally effective for acne. Their antimicrobial spectrum is very similar except for one important aspect: minocycline has better antistaphylococcal activity.

If minocycline is contraindicated and you need a different prescription, you may consider azithromycin, which also has anti-inflammatory properties.


  • 1. Dynacin prescribing information. PDR. 59th Edition. Montvale, NJ: Thomson PDR, 2005, p. 1957-1960

Last updated: February, 2015

Quick facts

  • Minocycline is a second-generation, long-acting tetracycline that was first introduced in 1967.
  • It is the most lipid soluble of all the tetracyclines. The importance of this property is that minocycline has particularly good penetration into lipid-rich tissues such as pilosebaceous unit.